Delta-9 tetrahydrocannabinol, commonly known as Delta-9 THC, is one of the primary psychoactive compounds found in the cannabis plant. When consumed in the form of gummies or other edibles, it interacts with the human body in a complex manner, leading to various physiological and psychological effects. Understanding the science behind Delta-9 THC gummies can shed light on how they work on the body.
Absorption and Metabolism:
The journey of Delta-9 THC gummies starts with ingestion. When you consume a Delta-9 THC-infused gummy, it goes through the digestive system, where it undergoes a process called first-pass metabolism. During this process, the Delta-9 THC is metabolized by the liver, primarily into its active form, 11-hydroxy-THC. This metabolite, 11-hydroxy-THC, is believed to be more potent and has a different onset and duration of effects compared to Delta-9 THC. It takes longer to reach its peak in the bloodstream and may have a longer-lasting impact, contributing to the unique characteristics of the Delta-9 THC gummy high.
Receptor Activation:
After metabolism, the active compounds in the best Delta 9 gummies enter the bloodstream, where they interact with the endocannabinoid system ECS. The ECS is a complex regulatory network of receptors, endocannabinoids naturally occurring compounds in the body, and enzymes that play a crucial role in maintaining homeostasis. Delta-9 THC primarily interacts with two types of cannabinoid receptors in the ECS – CB1 and CB2. CB1 receptors are primarily found in the central nervous system, including the brain, while CB2 receptors are more abundant in peripheral tissues, particularly in the immune system. Delta-9 THC’s psychoactive effects are mainly attributed to its interaction with CB1 receptors in the brain. When Delta-9 THC binds to CB1 receptors, it can modulate various physiological processes, leading to the sensation of being high. This includes altered perception, mood changes, and changes in sensory experiences. The exact mechanisms by which Delta-9 THC affects these processes are still the subject of ongoing research, but it is thought to involve the modulation of neurotransmitters, including dopamine and serotonin.
Neurotransmitter Modulation:
Delta-9 THC’s impact on neurotransmitters is one of the key reasons it produces its characteristic effects. It can enhance the release of dopamine, a neurotransmitter associated with pleasure and reward. This is why many individuals report feelings of euphoria and happiness when using Delta-9 THC gummies. Additionally, Delta-9 THC can affect the release and reuptake of other neurotransmitters, such as GABA and glutamate, which play crucial roles in regulating anxiety, stress, and cognitive function. This modulation can result in feelings of relaxation, altered perception of time, and changes in thought processes.
Short-Term and Long-Term Effects:
The effects of Delta-9 THC gummies can vary from person to person, depending on factors like the dose, individual tolerance, and the presence of other compounds in the gummies, such as other cannabinoids or terpenes. Typically, users experience a sense of relaxation, increased sociability, and altered sensory perception. Some may also experience heightened creativity and intensified sensory experiences, such as music or food. Scientific research on Delta-9 THC continues, and ongoing studies aim to better understand its effects and potential therapeutic applications.